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11-08-2010, 02:52 PM #1
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Bleached kraft pulpmill effluents and TCDD: Effects on biotransformation and testoste
By Pirjo Lindstrom-Seppa, Aimo Oikari
Marine Environmental Research, Volume 28, Issues 1-4, Responses of Marine Organisms to Pollutants, 1989, Pages 99-103, ISSN 0141-1136, DOI: 10.1016/0141-1136(89)90191-8.
The aim of this study was to examine the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, given intraperitoneally) alone and together with bleached kraft pulpmill effluents (BKME) on fish biotransformation reactions and testosterone levels in mature male rainbow trout (Salmo gairdneri Richardson). The results show extremely high induction in liver and kidney monooxygenase (PSMO) activities in 3 weeks caused by TCDD alone or TCDD together with BKME. BKME alone did not cause significant effects. 7-Pentoxyresorufin O-dealkylase activity, previously shown to be an indicator of phenobarbital-type induction, was shown to be highly inducible by TCDD in fish. Plasma testosterone levels, although decreased in another subacute exposure to BKME, showed only slight changes due to TCDD and TCDD + BKME.