Estrogenic effect of dioxin-like aryl hydrocarbon receptor (AhR) agonist (PCB congener 126) in salmon hepatocytes

Publication year: 2008
Source: Marine Environmental Research, Volume 66, Issue 1, July 2008, Pages 119-120</br>
Anne S., Mortensen , Augustine, Arukwe</br>
Previous studies have shown that aryl hydrocarbon receptor (AhR) agonists possess anti-estrogenic activities and several mechanisms have been proposed to explain the interactions between AhR and estrogen receptor (ER) signalling pathways. In the present study, we show that 3,3?4,4?5-pentachlorobiphenyl (PCB126 – a dioxin-like AhR agonist) produced estrogenic responses in the absence of ER agonist, in fish in vitro system. We exposed salmon primary hepatocytes to PCB126 (1, 10 and 50pM) and the ER agonist nonylphenol (NP; 5 and 10?M) singly and also in combination. Vitellogenin (Vtg) and zona radiata proteins (Zr-proteins) levels were analysed by semi-quantitative ELISA. We observed that...</br>

11th August 2010 12:14

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